This problem is killing me!
For example, if I enter my site by using this link: http://www.example.com/index.php
it works just fine. But when using the domain name only (http://www.example.com) without the page name and extension, it gives me the "HTTP Error 404 - File or directory not found."
Your IIS 6 site hasn't been configured to use index.php as an index page. It'll be looking for index.html or default.htm or something similar, which probably doesn't exist.
From the IIS manager right-click the web site entry and click on the Documents tab.
Ensure the Enable default content page box is checked, and add index.php to the top of the list.
You might need to stop and restart the web site.
This is for WCF Service.
Even I have the same issue! tried many ways and different options. I found that i have installed extra feature in Window Features.
Go to Control panel and find Turn windows Features on or off
check whether **
Internet Information Services Hostable Web Core is checked! if Checked un-check and re-boot machine.
And try now, you should be able to find your results.
If not there might be other reason. But this worked for me.