【菜鸟】trim_galore报错 Unable to create directory

bin_trim_galore=trim_galore
dir='~/bioinfo/rna/data01/srr/clean/'
cat $1 |while read id
do
        arr=(${id})
        fq1=${arr[0]}
        fq2=${arr[1]}
$bin_trim_galore -q 25 --phred33 --stringency 3 --paired -o $dir $fq1 $fq2
done
~                                                                                                                                                                                          
~                                                                                                                                                                                          
~            

sh文件如上图，bash之后就提示

Multicore support not enabled. Proceeding with single-core trimming.
Path to Cutadapt set as: 'cutadapt' (default)
Cutadapt seems to be working fine (tested command 'cutadapt --version')
Cutadapt version: 3.2
single-core operation.
Unable to create directory ~/bioinfo/rna/data01/srr/clean/ No such file or directory
 

是我dir设置的问题吗，是~还是/的问题？

>Unable to create directory ~/bioinfo/rna/data01/srr/clean/ No such file or directory  

你到这个目录的每一级，看你有权限创建目录或者写文件么？

虽然是买的服务器，但是是有权限的

请问这是个啥问题，纠结我有一会了